TABLE II.

Percentage Change in High-Resolution MRI Assessments (FSA Population)^*

Parameter	Month-18 Completers, N = 25†	P Value	Month-24 Completers, N = 21†	P Value	End Point, N = 32†‡	P Value
Surface-to-curve ratio§	2.37 (−9.44 to 14.18)	0.679	−2.38 (−19.54 to 14.66)	0.770	0.31 (−13.29 to 13.91)	0.963
Cortical thickness#	−0.59 (−6.27 to 5.09)	0.830	−0.69 (−7.08 to 5.70)	0.821	−0.97 (−5.99 to 4.06)	0.695
Bone volume fraction**	0.31 (−3.45 to 4.07)	0.865	−3.39 (−8.42 to 1.64)	0.172	−2.49 (−6.32 to 1.34)	0.193
Topological erosion index††	3.46 (−3.41 to 10.33)	0.305	8.82 (−1.28 to 18.92)	0.082	5.72 (−2.71 to 14.15)	0.175

^*FSA = full-set analysis.

^†The values are given as the least-squares mean percentage change from baseline, with the 95% CI in parentheses.

^‡Includes data for those subjects who dropped out prior to month 18 and had a follow-up MRI scan at the time they discontinued.

^§A measure of the ratio of plates to rods in the analysis volume.

^#A surface-based measurement.

^**A measure of mechanical competence of bone.

^††The ratio of the sum of topological parameters expected to increase with bone erosion compared with the sum of those expected to decrease³³.