Fig. 1.

Tumor-associated dendritic cells regulate T cell responsiveness in the tumor microenvironment. a The prostatic tumor microenvironment (TME) contains a variety of inflammatory cells that contribute to immune suppression. Tumor-associated dendritic cells (TADCs) tolerize CD8⁺ T cells that enter the TME in a FOXO3-dependent mechanism. Induction of this tolerogenic behavior by TADCs may be mediated by Treg cells, mast cells, or tumor-derived factors. b Provision of tumor-specific CD4⁺ T cells alters the TME and prevents tolerization of CD8⁺ T cells. This is in part mediated by the activation of TADC and down-regulation of FOXO3 expression by TADC