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Proposed model of p300 ligand function. I-CBP112 binding of p300 to leads to increased acetylation of histones, decreased p300-chromatin association, and no change in mRNA production. A-485 decreases nucleosome and transcription factor acetylation, p300-chromatin association, and mRNA production. Together the ligands abrogate p300-chromatin association and downregulate many mRNAs. Yellow circles indicate acetyl-Lys. All other shapes as labeled.
