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. 2019 Nov 14;4(22):e129035. doi: 10.1172/jci.insight.129035

Figure 2. HA-specific memory B cells following matched IIV boost vaccination.

Figure 2

(A) Representative plots of H5-specific IgG+ memory B cells (CD19+CD20+CD27+IgG+, animal 7777) from peripheral blood at day 0, 14, 28, 35, and 56 and mediastinal lymph nodes (LN), ipsilateral axillary lymph nodes, contralateral axillary lymph nodes, and spleen at day 56 after H5N1 pLAIV, which is 28 days after pIIV boost. (B) Frequency of H5+ or H1+ head-specific or H5+H1+ double-positive stem-specific memory B cells in peripheral blood at day 28, 35, 42, and 56 following H5N1 pLAIV-pIIV vaccination. (C) Frequency of H5+ or H1+ head-specific or H5+H1+ double-positive stem-specific memory B cells in submandibular, cervical, mediastinal, ipsilateral and contralateral axillary lymph nodes and spleen at day 56 after H5N1 pLAIV, which is 28 days after pIIV boost.