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. 2019 Nov 14;4(22):e126315. doi: 10.1172/jci.insight.126315

Figure 10. Induction of prelamin A expression in adulthood leads to a progressive and fatal decline in cardiac function in inducible csPLA-Tg (icsPLA-Tg) mice.

Figure 10

(A) Schematic showing the protocol for assessing the effect of prelamin A acquired in adult mouse myocardium via utilization of a tamoxifen inducible MerCreMer promoter. (B) Immunofluorescence staining of heart sections showing the expression of prelamin A in cardiomyocytes of icsPLA-Tg mice. Scale bar: 20 μm. (C) Kaplan-Meier survival analysis showing that csPLA-Tg male and female mice died early compared with FLctrl counterparts. Log-rank Mantel-Cox. P < 0.0001. n = 9/group. (D) Body weights remained constant during the course of the protocol. (E) Cardiac function declined progressively over the course of the protocol. Values are mean ± SD. n = 9–8 males and 1 female/group. Two-way ANOVA with repeated measures and Sidak’s test for multiple comparisons was performed. ****P < 0.0001.