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. 2019 Nov 14;4(22):e126315. doi: 10.1172/jci.insight.126315

Figure 9. Prelamin A accumulated in hearts of patients with HIV-associated cardiomyopathy under retroviral therapy.

Figure 9

(A) The DCM patient sample in which prelamin A accumulated showed profound mononuclear infiltration unlike other DCM samples. Scale bar: 40 μm. (B) H&E and CD3+ IHC showing inflammation in HIV+ myocardium consistent with the csPLA-Tg model. Scale bar: 30 μm. (C) IHC showing focal prelamin A accumulation in CM nuclei (black arrows) and non-CM populations (green arrows) of HIV+ myocardium supported by Western blotting, which detected accumulation of prelamin A in hearts of HIV patients. (D) Electron micrographs showing nuclear morphology defects in HIV+ myocardium (red arrow; scale bar: 3 μm) and nuclear pore complexes surrounded by evenly spread heterochromatin in nondiseased myocardium (large white arrows) and heterochromatin displacement in HIV+ myocardium (small white arrows). Arrows are located at the inner nuclear membrane of lower right panel of D. Scale bar: 1 μm. N, nucleus; L, lipid bodies.