Skip to main content
. 2019 Nov 14;4(22):e133083. doi: 10.1172/jci.insight.133083

Figure 1. Decreased CLEC7A transcripts in Y238X variants.

Figure 1

Violin plots showing maximum and minimum values, with boxes showing 25th and 75th percentile bounds and bisecting lines showing median values for GTEx cohort data. There is decreased CLEC7A gene expression in (A) whole blood of AC genotypes (n = 40) and CC genotypes (n = 4) compared with wild-type genotypes (AA, n = 325) as well as in (B) lung tissue of AC (n = 38) and CC (n = 5) genotype subjects compared with wild-type AA (n = 330, P = 0.0004) subjects. Comparisons were made by linear regression. (C) Box-and-whisker plots depict decreased CLEC7A gene expression in Y238X heterozygous cells stimulated for 4 hours with zymosan relative to control media. RT-PCR CLEC7A mRNA and reference ACTB mRNA was quantified as 2−ΔΔCt. Cells in control media were normalized to a value of 1 and comparisons were made using ANOVA with Dunnett’s correction.