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. 2019 Nov 14;4(22):e133083. doi: 10.1172/jci.insight.133083

Figure 5. Impaired survival in lung transplant recipients with Y238X variant genotypes in derivation and validation cohorts.

Figure 5

(A) Kaplan-Meier graph demonstrating survival in years after transplant in UCSF cohort subjects with loss-of-function CLEC7A polymorphisms compared with those with wild-type dectin-1 genotypes (multivariable HR 1.8, CI 1.1–3.8, P = 0.02). (B) In the LTOG cohort, overall survival in subjects stratified by CLEC7A genotype was also decreased in subjects with CLEC7A AC and CC variants compared with wild-type CLEC7A genotypes (multivariable HR 1.3, CI 1.1–1.6, P = 0.02). Risk for death was determined using Cox proportional hazards models adjusted for subject characteristics established as important for lung transplant outcomes.