Table 2.

Comparison of outcomes over 10 d after S. pneumoniae infection

Experimental group	Body weight	Temperature	Respiratory rate
Uninjured-infected over time (compared with pre-infection baseline)	*p = 0.0147 at day 1	*p < 0.05 at days 1, 4–5	*p < 0.05 at days 1,5
	*p = 0.0116 at day 2	**p < 0.01 at days 2,7	**p < 0.01 at days 2–3
	NS at days 3–10	NS at days 3, 8–10	NS at days 4, 6–10
T3Tx-Saline + infection over time (compared with pre-infection baseline)	*p < 0.05 at days 2–10	**p = 0.0078 at day 1	**p < 0.01 at days 1–2
		***p = 0.0007 at day 2	***p < 0.001 at days 3–4
		*p = 0.0169 at day 7	*p < 0.05 at days 5–9
		NS at days 3–6, 8–10	NS at day 10
T3Tx-XPro1595 + infection over time (compared with pre-infection baseline)	*p < 0.05 at day 1–9	*p < 0.05 at days 1,7	**p < 0.01 at days 1,4,6
	NS at day 10	**p = 0.0031 at day 2	***p < 0.001 at days 2–3
		NS at days 3–6, 8–10	*p = 0.0101 at day 5
			NS at days 7–10
T3Tx-Saline + infection versus uninjured-infected	NS at days 0–3	*p = 0.0384 at day 2	***p = 0.0001 at day 1
	*p = 0.0117 at day 4	NS at days 1, 3–10	****p < 0.0001 at days 2–4
	****p < 0.0001 at days 5–10		**p = 0.0015 at day 5
			NS at days 6, 8–10
			*p = 0.0454 at day 7
T3Tx-XPro1595 + infection versus Uninjured-infected	NS at days 0–3	NS at days 1–10	*p = 0.0367 at day 1
	**p = 0.0016 at day 4		****p < 0.0001 at day 2
	****p < 0.0001 at days 5–6		**p < 0.01 at days 3–4
	***p = 0.0003 at day 7		NS at days 5–10
	*p < 0.05 at days 8–9
	NS at day 10
T3Tx-Saline + infection versus T3Tx-XPro1595 + infection	NS at day 0–8	NS at days 1–10	NS at days 1, 3–10
	*p = 0.0293 at day 9		**p = 0.0085 at day 2
	**p = 0.0067 at day 10

NS, nonsignificant.