Table 2.

Common features of eRNAs.

Common features of eRNAs	Selected References	Comments
Produced at active enhancers	[21,82,104]
Non-coding transcripts	[78–80]
Transcribed by RNA Pol II	[8,78,82,88–90].
Not spliced	[81,96,97]	Spliced eRNA: [14]
Lack of polyadenylation	[78,90,96,100,101]	eRNAs with polyadenylation: [80,96]
Cell-type specific	[21,82,104]
Bidirectional transcription	[79,81–84]	Unidirectional transcription: [78,80,85–87]
Degraded by RNA Exosome	[78,90,96,100,101]
Regulated by Integrator	[95]
Average size 2kb – 5kb	[78–80]
Bind transcription factors	[58,89,98,117,126–131]
Release paused RNA Pol II	[90,133–135]
Contribute to enhancer-promoter looping	[63,89,92,94,99,108,142]	Exceptions: [82,90,143]
Interfere with transcriptional repressors	[90]