Figure 3.

Global reprogramming of sncRNA classes in lung and brain of HPAI H5N1 virus-infected ducks.

Non-metric multidimensional scaling (nMDS) analysis, based on Euclidian distance, was applied to normalized expression values (CPM) of 518 miRNAs, 470 piRNAs (with a mean expression of >10 CPM), 110 snoRNAs, and 10 snRNAs. Each dot is based on the average read count (three biological replicates) of each sncRNA species at the respective time point in lung and in brain. Both organ-specific and infection-driven changes are seen in miRNA, piRNA and snoRNA, but only infection-driven changes in snRNA.