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. 2019 Dec 3;6(4):271–333. doi: 10.1080/23328940.2019.1691896

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This work was authored as part of the Contributor’s official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.

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Figure 5. — Relationships between changes in NAc temperature and two temperature differentials (NAc-muscle and skin-muscle) during tail-pinch, social interaction and subcutaneous saline injection in freely moving rats. Graphs on the left side show time-dependent correlative relationships between changes in NAc temperature and two temperature differentials. In each case, increases in NAc temperature correlated with increases in NAc-muscle differentials and decreases in skin-muscle differentials. Graphs on the right side show that NAc temperature increases induced by each arousing stimulus were dependent on basal NAc temperatures; these responses were strong at low basal temperatures and progressively weaker at higher basal temperatures. Regression line crossed the line of no effect at ~39.0–39.5°C, suggesting upper limits for physiological brain temperature increase. Compiled from original data published in [57] and re-analyzed for this report.