Figure 17.

In vitro current responses of GLU- (A) and glucose- (B) selective (Active) and substrate-null (Null) biosensors to different concentrations of substrates before (Pre) and after (Post) an in vivo recording. (C) Current response of an example GLU biosensor at 20°C versus 37°C. Dashed lines represent the baseline current in vitro at each temperature, each arrow indicates the time when 10 µM GLU was added. Note that the baseline at 37°C is approximately equivalent to the current response to 10 µM GLU at 20°C. Right bar graph indicates the percent increase in current between 20°C and 37°C for the GLU and glucose sensors tested. Original data were published in [174,177]; the picture was reproduced in [187] (ACS Chemical Neuroscience; open access publication).