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. 2019 Dec 3;6(4):271–333. doi: 10.1080/23328940.2019.1691896

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This work was authored as part of the Contributor’s official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.

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Figure 19. — Slow changes in electrochemical currents detected by GLU and GLU-null sensors in the NAc shell (left panel) and NAc core (right panel) during a 3-min tail-pinch in freely moving rats. Top row (A and C) shows mean (±SEM) changes in total currents detected by both types of sensors. Middle row (B and D) shows current differences (active – null) calibrated in nM GLU concentrations. The two vertical hatched lines in each graph show onset and offset of tail-pinch and horizontal hatched lines show baselines. Two diagonal lines in A show the trend in current baselines calculated for GLU and GLU-null sensors. Asterisks in A show the period of significant differences in currents (current x time interaction assessed with two-way ANOVA) detected by active and null sensors. Significant differences in currents (active – null) are shown in B as filled symbols. E shows mean(±SEM) changes in NAc temperature and electrochemical current detected by GLU-null sensors during 3-min tail-pinch. Original data were published in [174,177]; the picture was reproduced in [187] (ACS Chemical Neuroscience; open access publication).