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. 2019 Dec 3;6(4):271–333. doi: 10.1080/23328940.2019.1691896

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This work was authored as part of the Contributor’s official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.

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Figure 22. — Changes in brain (NAc, nucleus accumbens; VTA, ventral tegmental area of midbrain, Hippo, hippocampus) and muscle temperatures during cocaine self-administration in trained rats. A and B = changes in absolute and relative temperatures averaged for each consecutive cocaine self-injection. L + S, the moment of light+sound presentation, when the lever became accessible and the rat could press a lever. C = temperature changes associated with the first-in-session cocaine self-injection. D = temperature changes associated with regular cocaine self-injections. E = differences in NAc temperature changes after a typical single-dose (1.0 mg/kg) and double-dose (2.0 mg/kg) cocaine self-injections. Data were replotted from [223].