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. 2019 Dec 3;6(4):271–333. doi: 10.1080/23328940.2019.1691896

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This work was authored as part of the Contributor’s official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.

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Figure 26. — State-dependency and environmental modulation of temperature responses induced by iv heroin (0.1 mg/kg) in freely moving rats. When heroin as injected during social interaction (yellow area from 0 to 60 min), temperature elevation and decrease in skin-muscle differentials became larger compared to the effects induced by this dug in quiet resting conditions. When heroin was injected at 29·C ambient temperatures, drug-induced temperature elevation became more prolonged. Data were replotted from [228].