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. 2019 Dec 3;6(4):271–333. doi: 10.1080/23328940.2019.1691896

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This work was authored as part of the Contributor’s official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.

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Figure 28. — A and B. Mean (±SEM) changes in NAc and muscle temperature and NAc-muscle temperature differentials following exposure to light+sound stimulus that was previously paired with heroin self-injections (conditioned sensory cue A) and preceding the first heroin self-injection of a session (B) in trained rats. Filled symbols show values significantly different from baseline (the last minute before the event). C. Changes in NAc-muscle temperature differentials during heroin self-administration session in trained rats. L + S = presentation of a conditioned sensory cue, symbols with numbers = consecutive heroin self-injections. Filled symbols show values significantly different from baseline (0 min). Data were replotted from [229].