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. 2019 Dec 3;6(4):271–333. doi: 10.1080/23328940.2019.1691896

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This work was authored as part of the Contributor’s official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.

This is an Open Access article that has been identified as being free of known restrictions under copyright law, including all related and neighboring rights (https://creativecommons.org/publicdomain/mark/1.0/). You can copy, modify, distribute and perform the work, even for commercial purposes, all without asking permission.

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Figure 30. — MDMA injected at a dose ~1/5 of the LD50 (9 mg/kg) at normothermic conditions (29°C) induces lethality in all tested rats. A = NAc temperature changes in individual animals; B = changes in NAc, muscle, and skin temperatures for the first 90 min from MDMA injection, when all rats were still alive; C = changes in NAc-muscle and skin-muscle differentials; D = changes in locomotor activity, E = changes in NAc-muscle differentials preceding and following termination of breathing in individual rats; F = mean changes in NAc-muscle and skin-muscle differentials preceding and following termination of breathing. Bar graphs show differences in temperature and locomotor effects for 90 min after MDMA injection at 23°C and 29°C. Original data were published in [237] (Journal of Neuroscience, open access).