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. 2020 Jan 8;6(2):eaax9605. doi: 10.1126/sciadv.aax9605

Fig. 3. Ablation of β-catenin in mature adipocyte resists long-term HFD–induced obesity.

Fig. 3

(A) Schematic of conditional β-catenin deletion in mature adipocytes with aP2-cre. (B) Body weight of control and APBKO mice at 3 and 8 weeks (n = 5 for each group at 3 weeks, n = 3 for each group at 8 weeks). (C) A representative photograph of 8-week-old control and APBKO mice. (D) Schematic of conditional β-catenin deletion in mature adipocytes with adiponectin-cre. (E) Comparison of β-catenin expression in mature adipocytes and SVF cells from brown adipose tissues (BAT), iWAT, and eWAT between chow diet–fed control and ABKO mice (n = 7 for each group). (F and G) Body weight curve of control and ABKO mice under chow diet (F) and HFD (G) (n = 15 to 19 for chow diet, n = 13 for HFD). (H) A representative photograph of 24-week HFD-fed control and ABKO mice. (I) Fat mass and lean mass in 24-week HFD-fed control and ABKO mice (n = 12 for each group). AD, adipocyte; ABKO, Adiponectin-cre;β-cateninflox/flox; APBKO, aP2-cre;β-cateninflox/flox; HFD, high-fat diet; SVF, stromal vascular fraction; BAT, brown adipose tissue; iWAT, inguinal white adipose tissue; eWAT, epididymal white adipose tissue. Data are shown as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.