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. 2019 Dec 20;11(24):12328–12344. doi: 10.18632/aging.102575

Figure 5.

Figure 5

The effects of S100A4 and p53 on CR-CC cell viability. (A, B) TUNEL assay was conducted to detect cell apoptosis ratio in CC cells. (C, D) Western Blot was used to determine the expression levels of cleaved Caspase-3 in CR-CC cells. CCK-8 assay was performed to detect the proliferation ability of (E) CR-HCT116 cells, (F) CR-SW480 cells and (G) CR-SW620 cells. (“Con” represented “Control group”, “Cis” indicated “Cisplatin treated group”, “Cis+KD-S” represented “Cisplatin plus downregulated S100A4 treated group”, “Cis+OE-p53” represented “Cisplatin plus overexpressed p53 treated group”). All the experiments repeated at least 3 times. “*” means p < 0.05, “**” means p < 0.01 and “NS” means no statistical significance.