Table 3. Comparison of the therapies presented in this review.

Therapy	Pros	Cons
Senolytics	High specificity  - Targeted drugs Sporadic treatments  - Depending on compound efficacy	Low specificity  - Non-targeted compounds Side effects  - BCL family inhibitors Increase in apoptotic bodies Chronic treatments  - Depending on compound efficacy
Senomorphics	High specificity  - Targeting individual SASP components Sporadic treatments  - Depending on compound efficacy	Low specificity  - Targeting central pathways Chronic treatments  - Depending on compound efficacy Lack of senescent cell clearance? Side effects
Improving immune system	High specificity  - Personalized treatments  - Immunotherapy Sporadic treatments Dietary interventions	Time consuming and expensive  - Personalized treatments Low specificity  - General activation Side effects  - Autoimmunity?  - Hematopoietic malignancies? Chronic treatments Patients affected by immunosuppression and/or immunosenescence
TIS	High specificity  - Specific targets Sporadic treatments Stops tumor growth Possibility to combine with other therapies	Low specificity  - General damage (chemo-radiotherapies) Side effects  - New tumors  - Fibrosis  Chronic treatments Increasing senescence burden