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. 2019 Dec 16;11(24):12177–12201. doi: 10.18632/aging.102559

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Copyright © 2019 Zilu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Knockdown of XIAP promotes HFD-induced oxidative stress in liver mice. (A) Calculation of ROS intensity, MDA, H₂O₂, O₂^-, XO, iNOS levels, and SOD, TAC, CAT, GST and GSH-Px activity in hepatic tissue samples from each group of mice. (B and C) Representative western blot analysis of the expression of SOD1, HO-1, Nrf2, and quantification of SOD1, HO-1, Nrf2, NQO-1 and GCLM in liver samples. (D) Representative images of immunohistochemical analysis for Nrf2, HO-1 and SOD1 expression in liver tissue sections. For all bar plots shown, data are expressed as the mean ± SEM. n = 8 per group. ^ap < 0.05 vs. ItsiRNA/SCD or ItsiXIAP/SCD. ^bp < 0.05 vs. ItsiRNA/HFD.