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. 2019 Dec 16;11(24):12532–12545. doi: 10.18632/aging.102586

Figure 4.

Figure 4

AZ3451 attenuates IL-1β induced apoptosis in chondrocytes. (A, B) Flow cytometry of Annexin V-FITC/PI staining and quantification data of the apoptosis rates in chondrocytes as treated above. (C, D) Representative western blots and quantification data of Bcl-2, BAX, Cyto C and Cleaved caspase 3 in chondrocytes as treated above. (E, F) Representative fluorescence photographs of mitochondrial membrane potential and JC-1 monomer rates in chondrocytes as treated above. (G, H) TUNEL staining assay was performed in chondrocytes as treated above. Data are shown as the mean ± SD. Significant differences between groups are indicated as ***P <0.001, **P < 0.01 and *P < 0.05.