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Core circadian clock genes are altered in thoracic cancers. (A) The circadian rhythm of core circadian genes, including CRY2, PER1, RORA, NR1D1, CLOCK, CRY1, PER3, PER2, and ARNTL. (B) The methylation difference between tumors and normal tissues. (C) The methylation level affects the core circadian gene expressions. Abbreviations: LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; ESCA, esophageal carcinoma.
