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. 2020 Jan 1;16(2):298–308. doi: 10.7150/ijbs.35075

Figure 6.

Figure 6

PARP1 knockout abolished the cardioprotective effect of 25-HC. Cardiac function post-IR in WT and PARP1 KO mice (A) Representative M-mode images and (B) statistical results (ejection fraction and fractional shorting) illustrated that cardiac systole function was ameliorated by 25-HC pretreatment (10 mg/kg). (C) Representative photographs of Evans blue/TTC double-stained murine heart slices obtained 24 h after IR injury. (D) Graphic representation of the LV infarct size and AAR: infarct size relative to AAR (I/AAR) and AAR relative to left ventricle (AAR/LV). Mean ± SEM. N = 5-6 per group, *P < 0.05 vs. vehicle group, #P < 0.01 vs. vehicle group.