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. 2019 Oct 1;48(2):556–567. doi: 10.1007/s10439-019-02362-6

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Mean (n = 9 for each sample group) depth-wise partitions of CA4+, normalized CA4+, and gadoteridol in cartilage 2 h after the immersion in dual or triple contrast agent. |——| represents the statistically significant (p < 0.05) difference between the contrast agent partition in the intact reference and proteoglycan (PG)-depleted (turquoise) or mechanically injured (red) sample and statistically significant (p < 0.05) correlation with PG distribution (dark green) within the superficial, middle, and deep zones. Partition is defined as contrast agent concentration in the cartilage divided by the concentration of the immersion bath. 0 denotes the articulating surface and 1 the cartilage-bone interface.