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. 2020 Jan 8;11:127. doi: 10.1038/s41467-019-13890-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Swab assays were conducted using both the wildtype R265 strain and two independent msh2Δ::NEO mutants to test for the ability to generate resistance to 5FC. All three strains developed resistance; however, the mismatch repair mutants generated resistant isolates at a higher frequency. b A fluctuation assay was conducted to compare 5FC resistance quantitatively between wildtype R265 and two independent msh2Δ::NEO mutants. Mutation rate was normalized to the wildtype strain. Red is used to indicate wildtype strains while green indicates msh2 deletion strains. Both mutator strains showed a greater than 15-fold increase in the rate of resistance. Data shown are the mean of 10 replicates and error bars indicate 95% confidence intervals.