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. 2020 Jan 9;10(1):2. doi: 10.1038/s41408-019-0267-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Passing–Bablok (a) and Bland–Altman (b) analyses were performed using 187 serum samples from patients with newly diagnosed or relapsed multiple myeloma (MM, n = 33), light-chain multiple myeloma (LCMM, n = 8) or smoldering multiple myeloma (SMM, n = 6). Shown are the results for the determination of κ and λ FLC and κ/λ ratio determined by N Latex FLC and Freelite. Bland–Altman plots reveal agreement between N Latex FLC and Freelite. A positive bias indicates higher values for the determination of FLC by Freelite compared with N Latex FLC. For a better representation of FLC results, two samples with extreme κ FLC results were not shown (sample 1: κ FLC results of Freelite: 14500 mg/l, N Latex FLC: 11200 mg/l, Sebia FLC: 3456 mg/l; sample 2: κ FLC results of Freelite: 31800 mg/l, N Latex FLC: 5880 mg/l, Sebia FLC: 6093 mg/l).