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. 2020 Jan 9;10(1):2. doi: 10.1038/s41408-019-0267-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The results of κ and λ FLC and κ/λ ratio determination by Sebia FLC are compared with N Latex FLC and Freelite results using 187 serum samples from patients with newly diagnosed or relapsed multiple myeloma (MM, n = 33), light-chain multiple myeloma (LCMM, n = 8), or smoldering multiple myeloma (SMM, n = 6). Shown are the results of Passing–Bablok (a) and Bland–Altman (b) analyses. Bland–Altman plots indicate agreement between FLC assays. A positive bias indicates higher values for determination of FLC by Freelite or N Latex FLC compared with Sebia FLC. For a better representation of FLC results, four samples with extreme κ FLC results or κ/λ ratios were not shown (sample 1: κ FLC results of Freelite: 14,500 mg/l, N Latex FLC: 11,200 mg/l, Sebia FLC: 3456 mg/l; sample 2: κ FLC results of Freelite: 31,800 mg/l, N Latex FLC: 5880 mg/l, Sebia FLC: 6093 mg/l; sample 3: κ/λ ratios of Freelite: 62,281, N Latex FLC: 727, Sebia FLC: 214; sample 4: κ/λ ratios of Freelite: 27146, N Latex FLC: 605, Sebia FLC: 406).