Table 2.
Concordance of FLC measurements.
| (A) Concordance of κ FLC | ||||||||
|---|---|---|---|---|---|---|---|---|
| κ FLC | N Latex FLC | κ FLC | Sebia FLC | κ FLC | Sebia FLC | |||
| Freelite | Normal | Abnormal | Freelite | Normal | Abnormal | N Latex FLC | Normal | Abnormal |
| Normal | 70 (37%) | 11 (6%) | Normal | 64 (34%) | 12 (7%) | Normal | 65 (35%) | 16 (9%) |
| Abnormal | 6 (3%) | 100 (54%) | Abnormal | 13 (7%) | 98 (52%) | Abnormal | 12 (6%) | 94 (50%) |
| Cohens Kappa coefficient: 0.81 | Cohens Kappa coefficient: 0.72 | Cohens Kappa coefficient: 0.69 | ||||||
| (B) Concordance of λ FLC | ||||||||
| λ FLC | N Latex FLC | λ FLC | Sebia FLC | λ FLC | Sebia FLC | |||
| Freelite | Normal | Abnormal | Freelite | Normal | Abnormal | N Latex FLC | Normal | Abnormal |
| Normal | 50 (27%) | 22 (12%) | Normal | 44 (23%) | 28 (15%) | Normal | 40 (21%) | 26 (14%) |
| Abnormal | 16 (8%) | 99 (53%) | Abnormal | 18 (10%) | 97 (52%) | Abnormal | 22 (12%) | 99 (53%) |
| Cohens Kappa coefficient: 0.56 | Cohens Kappa coefficient: 0.47 | Cohens Kappa coefficient: 0.43 | ||||||
| (C) Concordance of κ/λ ratio | ||||||||
| κ/λ ratio | N Latex FLC | κ/λ ratio | Sebia FLC | κ/λ ratio | Sebia FLC | |||
| Freelite | Normal | Abnormal | Freelite | Normal | Abnormal | N Latex FLC | Normal | Abnormal |
| Normal | 42 (22%) | 11 (6%) | Normal | 34 (18%) | 19 (10%) | Normal | 39 (21%) | 13 (7%) |
| Abnormal | 10 (5%) | 124 (67%) | Abnormal | 17 (9%) | 117 (63%) | Abnormal | 12 (6%) | 123 (66%) |
| Cohens Kappa coefficient: 0.72 | Cohens Kappa coefficient: 0.52 | Cohens Kappa coefficient: 0.66 | ||||||
Assay-specific reference ranges were used for the classification of a normal (within reference range) and abnormal (outside reference range) FLC. Determination of κ, λ, and κ/λ ratio concordances were performed using 187 serum samples