Table 3.

Concordance of iFLC/niFLC.

(A) Comparison of Freelite thresholds for MM requiring treatment (iFLC/niFLC ratio ≥ 100) and high-risk SMM (iFLC/niFLC ratio > 20) with N Latex FLC and Sebia FLC.
iFLC/niFLC	N Latex FLC		Sebia FLC
Freelite	<100	≥100	<100	≥100
<100	23 (56%)	1 (2%)	23 (55%)	1 (2%)
≥100	9 (21%)	9 (21%)	10 (24%)	8 (19%)
	Cohens Kappa coefficient: 0.49		Cohens Kappa coefficient: 0.43
Freelite	≤20	>20	≤20	>20
≤20	13 (31%)	0 (0%)	13 (31%)	0 (0%)
>20	9 (21%)	20 (48%)	7 (17%)	22 (52%)
	Cohens Kappa coefficient: 0.58		Cohens Kappa coefficient: 0.66

(B) Use of assay-specific thresholds for MM requiring treatment (iFLC/niFLC ratio ≥ 100/ ≥ 50/ ≥ 20) and high-risk SMM (iFLC/niFLC ratio > 20/ > 8/ > 8).
iFLC/niFLC	N Latex FLC		Sebia FLC
Freelite	<50	≥50	≤20	>20
<100	23 (55%)	1 (2%)	18 (43%)	6 (14%)
≥100	5 (12%)	13 (31%)	2 (5%)	16 (38%)
	Cohens Kappa coefficient: 0.70		Cohens Kappa coefficient: 0.62

iFLC/niFLC	N Latex FLC iFLC/niFLC		Sebia FLC iFLC/niFLC
Freelite	≤8	>8	≤8	>8
≤20	12 (29%)	1 (2%)	12 (29%)	1 (2%)
>20	2 (5%)	27 (64%)	2 (5%)	27 (64%)
	Cohens Kappa coefficient: 0.84		Cohens Kappa coefficient: 0.84