Table 1.
APE1-PPI bad prognostic signatures top regulators analysis.
| Dataset | Top1 | Top1 Bibliography | Gene Symbol Description | Top2 | Top2 Bibliography | Gene Symbol Description | Top3 | Top3 Bibliography | Gene Symbol Description |
|---|---|---|---|---|---|---|---|---|---|
| HNSC | XRCC6 | (1) (2) (3) | X-ray repair cross-complementing protein 6 | PRKDC | (1) (2) (3) | Protein kinase, DNA-activated, catalytic subunit | TERF2 | (1) (2) (3) | Telomeric repeat binding factor 2 |
| KIRC | PRKCD | (1) (2) (3) | Protein kinase C delta type | PPP1CB | (2) | Protein phosphatase 1 catalytic subunit beta | YBX1 | (1) (2) (3) | Y-Box binding protein 1 |
| LUAD | PRKN | (2) | Parkin RBR E3 ubiquitin protein ligase | HDAC2 | (1) (2) (3) | Histone deacetylase 2 | XRCC6 | (1) (2) (3) | X-ray repair cross-complementing protein 6 |
| UVM | SMYD2 | (1) (2) (3) | SET and MYND domain containing 2 | KDM1A | (1) (2) (3) | Lysine demethylase 1 A | XRCC5 | (1) (2) | X-ray repair cross-complementing protein 5 |
| LGG | SETD7 | (1) (2) (3) | SET domain containing 7, histone lysine Methyltransferase | KDM1A | (1) (2) (3) | Lysine demethylase 1A | CUL1 | (1) (2) | Cullin-1 |
| SKCM | DDB1 | (1) (2) (3) | Damage specific DNA binding protein 1 | PTP4A3 | (1) (2) (3) | Protein tyrosine phosphatase 4A3 | XRCC6 | (1) (2) (3) | X-ray repair cross-complementing protein 6 |
| LIHC | PRKN | (2) | Parkin RBR E3 ubiquitin protein ligase | HDAC2 | (1) (2) (3) | Histone deacetylase 2 | XRCC6 | (1) (2) (3) | X-ray repair cross-complementing protein 6 |
| KIRP | YBX1 | (1) (2) (3) | Y-Box binding protein 1 | PTP4A3 | (1) (2) (3) | Protein tyrosine phosphatase 4A3 | TCF21 | (1) (2) (3) | Transcription factor 21 |
| BRCA | DDB1 | (1) (2) (3) | Damage specific DNA binding protein 1 | XRCC6 | (1) (2) (3) | X-ray repair cross-complementing protein 6 | IDE | (1) (2) | Insulin-degrading enzyme |
| BLCA | DDB1 | (1) (2) (3) | Damage specific DNA binding protein 1 | XRCC5 | (1) (2) | X-ray repair cross-complementing protein 5 | TRIM28 | (1) (2) (3) | Tripartite motif containing 28 |
| PAAD | YBX1 | (1) (2) (3) | Y-Box binding protein 1 | ACTL6A | (1) (2) | Actin-like protein 6A | HNRNPK | (1) (2) (3) | Heterogeneous nuclear ribonucleoprotein K |
GeneXplain identification of the Top 3 putative master regulators (ranked by ascending Ranks sum) of bad prognostic genes in the 11 selected TCGA cancer datasets. Numbers in brackets refer to the presence of bibliographic evidence associating upstream regulators with proliferation (1), apoptosis (2) and resistance (3), respectively. For TCGA abbreviations, see Supplementary Table S6; for all the references Supplementary Table S7.