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. 2020 Jan 8;6:4. doi: 10.1038/s41531-019-0105-5

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2020

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Fig. 3 — A schematic overview of the possible repair strategies for the nigrostriatal pathway. The figure depicts the same circuit diagram schematic shown in Fig. 1 with circuit connections removed. The top left inset includes the various cell sources used (Consideration 1). The red, green, and yellow arrows indicate the various locations that cells have be implanted (Consideration 2). The inset to the right shows a preformed construct solution to restore the nigrostriatal pathway, including dopaminergic cell bodies in the SNpc, the inputs to those dopaminergic cells from other neural structures, and their long axonal outputs to the striatum. NUC nucleus; SUB substantia.