Table 4.
Comparison of MLE to NFDPM/ACM and nicotine between products within a user group.
| User group | Product | MLE to NFDPM (mg/session) | MLE to ACM (mg/session) | MLE to nicotine (mg/session) | MLE to NFDPM (mg/day) | MLE to ACMa (mg/day) | MLE to nicotineb (mg/day) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean (±SD) | Tukey’s rankingc | Mean (±SD) | Tukey’s rankingc | Mean (±SD) | Tukey’s rankingc | Mean (±SD) | Tukey’s rankingc | Mean (±SD) | Tukey’s rankingc | Mean (±SD) | Tukey’s rankingc | ||
| 1 | C651 | 19.0 (±7.7) | a | — | — | 1.55 (±0.63) | a | 256.4 (±150.4) | a | — | — | 20.9 (±12.3) | a |
| THS2.4(T) | 9.6 (±5.0) | b | — | — | 0.98 (±0.51) | b | 89.9 (±84.6) | b | — | — | 9.1 (±8.6) | b | |
| IS1.0(T) | — | — | 180.1 (±137.8) | — | 0.69 (±0.53) | c | — | — | 1883.1 (±897.6) | — | 7.3 (±3.5) | b | |
| 2 | IS1.0(T) | — | — | 209.2 (±157.4) | — | 0.80 (±0.60) | — | — | — | 1914.2 (±679.4) | — | 7.4 (±2.6) | — |
| 3 | C651 | 16.7 (±7.6) | a | — | — | 1.36 (±0.62) | a | 218.2 (±141.9) | a | — | — | 17.8 (±11.6) | a |
| THP1.0(T) | 4.7 (±2.9) | b | — | — | 0.34 (±0.21) | b | 36.7 (±40.4) | b | — | — | 2.7 (±2.9) | b | |
aMLE to ACM/day was calculated from MLE to nicotine/day using the relationship between ACM and nicotine, determined from calibration smoking (see section 2.4.2).
bFor IS1.0(T), MLE to nicotine per day was calculated by multiplying the average daily consumption e-liquid (mL) per day by the concentration of nicotine (mg/mL) in the cartridge.
cDifferent letters within a group indicate statistically significant differences (p < 0.05) between mean values.