Table 5.
Comparison of MLE to NFDPM/ACM and nicotine between user groups.
| Product | User group | MLE to NFDPM (mg/session) | MLE to ACM (mg/session) | MLE to nicotine (mg/session) | MLE to NFDPM (mg/day) | MLE to ACMa (mg/day) | MLE to nicotineb (mg/day) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean (±SD) | Pr > (t)c | Mean (±SD) | Pr > (t)c | Mean (±SD) | Pr > (t)c | Mean (±SD) | Pr > (t)c | Mean (±SD) | Pr > (t)c | Mean (±SD) | Pr > (t)c | ||
| C651 | 1 | 19.0 (±7.7) | 0.1201 | — | — | 1.55 (±0.63) | 0.1195 | 256.4 (±150.4) | 0.1471 | — | — | 20.9 (±12.3) | 0.1467 |
| 3 | 16.7 (±7.6) | 1.36 (±0.62) | 218.2 (±141.9) | 17.8 (±11.6) | |||||||||
| IS1.0(T) | 1 | — | — | 180.1 (±137.8) | 0.2735 | 0.69 (±0.53) | 0.2698 | — | — | 1883.1 (±897.6) | 0.6693 | 7.3 (±3.5) | 0.6693 |
| 2 | 209.2 (±157.4) | 0.80 (±0.60) | 1914.2 (±679.4) | 7.4 (±2.6) | |||||||||
aMLE to ACM/day was calculated from MLE to nicotine/day using the relationship between ACM and nicotine, determined from calibration smoking (see section 2.4.2).
bFor IS1.0(T), MLE to nicotine per day was calculated by multiplying the average daily consumption e-liquid (mL) per day by the concentration of nicotine (mg/mL) in the cartridge.
cValues > 0.05 indicate no statistically significant difference.