Table 1.

Binding kinetics of ligelizumab and omalizumab variants for human IgE.

Anti-IgE antibody	Association ka (M−1s−1)	Dissociation kd (s−1)	Affinity KD (pM)
Ligelizumab IgG	1.8 × 106	3.3 × 10−5	17.8
Omalizumab IgG	9.1 × 105	2.4 × 10−3	2659
Ligelizumab F(ab′)2	4.2 × 106	5.1 × 10−5	12.1
Omalizumab F(ab′)2	8.7 × 105	2.6 × 10−3	2998
Ligelizumab Fab	9.2 × 106	3.2 × 10−4	35.0
Omalizumab Fab	1.5 × 106	4.6 × 10−3	3090