Table 3.

Mean difference in ASSESS scores between visits. Negative values indicate a lower ASSESS score at the follow up visit.

Interval	Asthma outcome	n (%) with outcome	Change in ASSESS score		Mean difference in ASSESS score (95% CI)	p-value
			Participants without outcome mean (SD)	Participants with outcome mean (SD)
Baseline – 12 months	ACT score, ≥3 point increase	169 (28.3)	−0.20 ± 2.23	−3.15 ± 2.34	−2.95 (−3.36, −2.54)	< 0.001
	FEV1, ≥10% absolute increase	84 (15.1)	−0.77 ± 2.49	−2.86 ± 2.77	−2.08 (−2.67, −1.50)	< 0.001
	Medication, decrease of ≥2	35 (6.3)	−0.90 ± 2.50	−3.80 ± 3.11	−2.90 (−3.77, −2.02)	< 0.001
	AQLQ score, ≥0.5 point increase	159 (26.6)	−0.44 ± 2.36	−2.73 ± 2.62	−2.29 (−2.74, −1.84)	< 0.001
12-24 months	ACT score, ≥3 point increase	111 (18.6)	0.41 ± 2.12	−2.46 ± 2.72	−2.88 (−3.35, −2.40)	< 0.001
	FEV1, ≥10% absolute increase	60 (11.8)	−0.01 ± 2.45	−1.72 ± 2.79	−1.71 (−2.38, −1.04)	< 0.001
	Medication, decrease of ≥2	5 (1.0)	−0.17 ± 2.52	−4.00 ± 3.16	−3.82 (−6.06, −1.60)	0.001
	AQLQ score, ≥0.5 point increase	117 (19.6)	0.21 ± 2.30	−1.62 ± 2.85	−1.83 (−2.33, −1.32)	< 0.001
24-36 months	ACT score, ≥3 point increase	97 (16.2)	0.21 ± 2.00	−2.25 ± 2.17	−2.46 (−2.92, −2.00)	< 0.001
	FEV1, ≥10% absolute increase	59 (12.7)	−0.02 ± 2.08	−2.18 ± 2.60	−2.16 (−2.75, −1.57)	< 0.001
	Medication, decrease of ≥2	11 (2.3)	−0.27 ± 2.23	−1.45 ± 3.35	−1.18 (−2.53, 0.17)	0.087
	AQLQ score, ≥0.5 point increase	101 (16.9)	0.12 ± 2.12	−1.48 ± 2.41	−1.50 (−1.98, −1.01)	< 0.001