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. 2019 Dec 15;58(24):3509–3519. doi: 10.2169/internalmedicine.2696-19

Figure 1.

Figure 1.

Flow chart of the diagnosis. PCR testing was performed using bronchoalveolar lavage fluid samples from 109 patients. The diagnoses of the 109 patients on discharge included AIP (n=8), AFOP/COP/CEP (n=33), pneumonia (n=24), DILD (n=19), CTD-ILD (n=15), unclassifiable IP (n=4), AHP (n=3), AEP (n=2), and radiation-primed OP (n=1). PCR testing was positive in 60 of the patients, among whom 7 were finally re-diagnosed as having diseases other than viral pneumonia: COP (n=5), radiation-primed OP (n=1), and AEP (n=1). The final diagnosis included viral pneumonia in 53 patients and diseases other than viral pneumonia in 56 patients: unclassifiable IP (n=2); AFOP, COP, or CEP (n=11); radiation-primed OP after breast cancer (n=1); AEP (n=3); AHP (n=3); CTD-ILD [n=12; polymyositis (n=3); dermatomyositis (n=2); amyopathic dermatomyositis with MDA5 antibody (n=2); antisynthetase syndrome (n=5); and rheumatoid arthritis (n=1)], DILD (n=18), and pneumonia due to unknown pathogens (n=4). AEP: acute eosinophilic pneumonia, AFOP: acute fibrinous and organizing pneumonia, AHP: acute hypersensitivity pneumonitis, AIP: acute interstitial pneumonia, CEP: chronic eosinophilic pneumonia, COP: cryptogenic organizing pneumonia, CTD: connective tissue diseases, DILD: drug-induced-ILD, ILD: interstitial lung diseases, IP: interstitial pneumonia, OP: organizing pneumonia, PCR: polymerase chain reaction