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. 2019 Jul 1;12(7):2496–2505.

Figure 5.

Figure 5

IGFBP1 is a direct target of miR-519a in GC cells. A. The predicted target sequence in the 3’-UTR of IGFBP1 for miR-519a binding. B. The luciferase activity of the IGFBP1 3’-UTR-WT was decreased by miR-519a overexpression but was increased by miR-519a expression reduction, which indicated that IGFBP1 is a direct target of miR-519a. ***P < 0.001 vs. control group. GC, gastric cancer; IGFBP1, insulin-like growth factor binding protein 1; miR-519a, microRNA519a; MT, mutant-type; NC, negative control; UTR, untranslated region; WT, wild-type.