Table 3.
Distribution of mutations in rpsL and rrs conferring the spoligotype of 302 clinical Mycobacterium tuberculosis isolates
| Locus | Mutation patterns | No. of isolates | No. of genotype isolates | ||||
|---|---|---|---|---|---|---|---|
|
|
|
|
|||||
| DNA | Protein | STR-S | STR-R | MDR-TB | Beijing | Non-Beijing | |
| rpsL | AAG128AGG | Lys43Arg | 4 | 115 | 0 | 115 | 4 |
| AAG128ACG | Lys43Thr | 0 | 1 | 66 | 1 | 0 | |
| AAG128ATG | Lys43Met | 1 | 1 | 1 | 2 | 0 | |
| AAG129AAT | Lys43Asn | 0 | 1 | 0 | 1 | 0 | |
| AAG262CAG | Lys88Gln | 1 | 1 | 1 | 2 | 0 | |
| AAG263AGG | Lys88Arg | 2 | 17 | 7 | 19 | 0 | |
| rrs | A514T | 2 | 1 | 1 | 2 | 1 | |
| A514C | 3 | 26 | 12 | 29 | 0 | ||
| C517T | 2 | 5 | 2 | 6 | 1 | ||
| G848T | 0 | 1 | 1 | 1 | 0 | ||
| A906G | 0 | 1 | 0 | 1 | 0 | ||
| Total | 15 | 170 | 91 | 179 | 6 | ||
Abbreviations: STR, streptomycin; S, sensitive; R, resistant.