Table 6.
Downregulation of CCL18 mRNA expression in SKOV3 cells
| Group | Relative CCL18 mRNA, mean ± standard deviation | P-value |
|---|---|---|
| SKOV3 | 0.075 ± 0.014 | 0.001a |
| SKOV3-pSilencer | 0.069 ± 0.022 | 0.001b |
| SKOV3-CCL18-siRNA127 | 0.004 ± 0.002 | |
| SKOV3-control | 0.048 ± 0.013 | 0.013c |
CCL18 mRNA expression in SKOV3 cells was compared by one-way analysis of variance. A significant difference was found between groups (P = 0.002). LSD method was used for pairwise comparison and it demonstrated that CCL18 mRNA expression was significantly lower in SKOV3-CCL18-siRNA127 than that in other groups.
a
SKOV3-CCL18-siRNA127 vs. SKOV3;
b
SKOV3-CCL18-siRNA127 vs. SKOV3-pSilencer;
c
SKOV3-CCL18-siRNA127 vs. SKOV3-control.
CCL18, chemokine ligand 18.