Figure 1.

Sirt6 mRNA and protein expression were up-regulated in renal cancer tissues and cells. A. Sirt6 protein expression was up-regulated in renal tumor tissues from patients (T) compared to the paired non-tumor tissues (N). B. Immunohistochemistry analysis showed strong positive signal of Sirt6 in tumor tissues (scale bar: 50 μm). C. The expression of Sirt6 was increased in 786-O renal cancer cells, compared with normal control renal cell line HK-2 cells by Western blotting assay. β-tubulin was used as an internal control. D. Sirt6 mRNA expression was up-regulated in 786-O renal cancer cells, compared to control HK-2 cells. All data were presented as mean ± SEM. and analyzed by student’s t-test, *P < 0.05. N, none tumor; T, tumor.