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. 2020 Jan 1;7(Pt 1):105–112. doi: 10.1107/S2052252519016142

Table 3. Bioactivity of exemestane and the co-crystal.

Sample Urease inhibition activity (IC50 in µM ± SEM) Anti-cancer activity MCF-7 cell line (IC50 in µM ± SEM) Cytotoxicity against 3T3 normal fibroblast cell line (IC50 in µM ± SEM)
EX (API) NA Not evaluated >30
Co-crystal (EX:TH) 3.86 ± 0.31 Inactive >30
Standard Thio­urea 21.0 ± 1.45 Doxorubicin 0.924 ± 0.01 Cyclo­heximide 0.26 ± 0.12