Table 3. Bioactivity of exemestane and the co-crystal.
| Sample | Urease inhibition activity (IC50 in µM ± SEM) | Anti-cancer activity MCF-7 cell line (IC50 in µM ± SEM) | Cytotoxicity against 3T3 normal fibroblast cell line (IC50 in µM ± SEM) |
|---|---|---|---|
| EX (API) | NA | Not evaluated | >30 |
| Co-crystal (EX:TH) | 3.86 ± 0.31 | Inactive | >30 |
| Standard | Thiourea 21.0 ± 1.45 | Doxorubicin 0.924 ± 0.01 | Cycloheximide 0.26 ± 0.12 |