Table 2.

Correlations between the protein expression of Shh, Gli1, FAK, p-FAK, and p-AKT with the clinicopathological parameters of hepatocellular carcinoma

Group	Case	Shh		Gli1		FAK		p-FAK		p-AKT
		+	P	+	P	+	P	+	P	+	P
Gender
Male	43	25	0.23	26	0.64	25	0.08	16	0.56	22	0.48
Female	7	6		3		1		4		2
Age
≤ 50	15	11	0.35	11	0.15	10	0.17	5	0.53	8	0.62
> 50	35	20		18		16		15		16
Tumor diameter (cm)
≤ 3	13	6	0.20	2	0.00	3	0.15	4	0.43	2	0.01
> 3	37	25		27		23		16		22
HBV infection
-	6	2	0.27	2	0.39	3	0.92	5	0.06	4	0.59
+	44	29		27		23		15		20
AFP (μg/L)
≤ 400	15	12	0.12	6	0.09	7	0.62	8	0.21	10	0.08
> 400	35	19		23		19		12		14
Differentiation
High	31	21	0.29	14	0.02	8	0.00	11	0.41	7	0.00
Low	19	10		15		18		9		13
Cancer capsular integrity
Intact	26	12	0.02	7	0.00	9	0.01	5		5	0.00
Violated	24	19		22		17		15	0.00	19
Portal vein invasion
-	30	12	0.00	14	0.04	10	0.00	8	0.02	6	0.00
+	20	19		15		16		12		18
TNM stage
I, II	33	17	0.03	15	0.01	13	0.01	22	0.18	10	0.00
III, IV	17	14		14		13		8		14
Metastasis
Absence	22	9	0.00	4	0.00	7	0.01	18	0.01	6	0.00
Presence	28	22		25		19		12		18

Note: P < 0.05 was considered to indicate a significant difference between values. Shh, sonic hedgehog; Gli1, hedgehog transcription factor glioma-associated oncogene 1; FAK, focal adhesion kinase; p-FAK, phosphorylated focal adhesion kinase; p-AKT, phosphorylated protein kinase B; HBV, Hepatitis B virus; AFP, a-fetoprotein.