Table 1.
Relationship between CA XII overexpression and clinicopathologic characteristics of HCC patients in TMA specimens and TCGA data
| Clinical feature | TMA | TCGA | |||||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| Case | High, n (%) | χ2 | P-value | Case | Mean ± SD | P-value | |
| 90 | 37 (41.1) | 335 | |||||
| Gender | |||||||
| Male | 74 | 32 (43.2) | 0.782 | 0.377a | 227 | 1053.97±2689.60 | 0.011*,b |
| Female | 16 | 5 (31.3) | 108 | 1786.45±4145.06 | |||
| Age, years | |||||||
| < 60 | 68 | 23 (33.8) | 6.102 | 0.013*,a | 159 | 1609.59±4148.86 | 0.483b |
| ≥ 60 | 22 | 14 (63.6) | 176 | 1001.49±2086.70 | |||
| Race category | |||||||
| White | na | na | na | na | 164 | 1796.99±4097.35 | 0.297c |
| Black or African American | na | na | na | 14 | 492.52±700.84 | ||
| Asian | na | na | na | 155 | 770.56±1937.35 | ||
| American Indian or Alaska native | na | na | na | 2 | 5574.21±7879.17 | ||
| Tumor size (cm) | |||||||
| > 5 | 42 | 23 (54.8) | 6.061 | 0.014*,a | na | na | na |
| ≤ 5 | 48 | 14 (29.2) | na | na | |||
| Tumor encapsulation | |||||||
| None | 43 | 17 (39.5) | 0.085 | 0.771a | na | na | na |
| Complete | 47 | 20 (42.6) | na | na | |||
| Tumor number | |||||||
| Multiple | 16 | 10 (62.5) | 3.677 | 0.055a | na | na | na |
| Solitary | 74 | 27 (36.5) | na | na | |||
| Hepatitis B virus infection | |||||||
| Yes | 77 | 34 (44.2) | 2.041 | 0.153a | na | na | na |
| No | 13 | 3 (23.1) | na | na | |||
| Liver cirrhosis | |||||||
| Yes | 78 | 33 (42.3) | 0.346 | 0.556a | na | na | na |
| No | 12 | 4 (33.3) | na | na | |||
| Pathologic grade | |||||||
| Grade 1 | 2 | 0 (0.00) | 8.380 | 0.015*,a | 45 | 854.22±1785.68 | 0.012*,c |
| Grade 2 | 63 | 21 (33.3) | 161 | 1232.96±3525.96 | |||
| Grade 3 | 25 | 16 (64.0) | 117 | 1627.08±3408.58 | |||
| Grade 4 | 0 | 12 | 406.06±572.01 | ||||
| TNM stage | |||||||
| Stage I | 61 | 22 (36.1) | 1.991 | 0.158a | 164 | 1058.96±2840.99 | 0.130c |
| Stage II | 29 | 15 (51.7) | 83 | 1125.12±2447.09 | |||
| Stage III | 0 | 83 | 1488.47±3216.30 | ||||
| Stage IV | 0 | 5 | 8318.16±12210.66 | ||||
*
P < 0.05;
a
χ2;
b
Mann-Whitney U test;
c
Kruskal-Wallis test;
Adequate amounts of clinical data for 39 HCC patients from the TCGA were unavailable. CA XII, carbonic anhydrase XII; HCC, hepatocellular carcinoma; TMA, tissue microarray; TCGA, The Cancer Genome Atlas; SD, standard deviation; TNM, Tumor Node Metastasis.