Table 4.
Evaluation of risks for CRC
| Variable | Number | Unadjusted | Number | Adjusted | ||
|---|---|---|---|---|---|---|
|
|
|
|||||
| Case/control | OR | 95% CI | Case/control | OR | 95% CI | |
| BMI by tertile (kg/m2) | ||||||
| ≤ 22.7 | 67/96 | 1.00 | 67/96 | 1.00 | ||
| 22.7-23.8 | 120/95 | 1.67 | 0.51-2.94 | 120/95 | 1.37 | 0.42-2.05 |
| > 23.8 | 171/95 | 2.89 | 0.94-7.02 | 171/95 | 2.11 | 0.87-6.28 |
| Trend test | P = 0.078 | Pa = 0.162 | ||||
| WHR by tertile | ||||||
| ≤ 0.84 | 62/95 | 1.00 | 62/95 | 1.00 | ||
| 0.84-0.87 | 111/96 | 1.97 | 1.17-6.28 | 111/96 | 1.73 | 1.04-5.92 |
| > 0.87 | 185/95 | 3.36 | 1.67-9.06 | 185/95 | 2.99 | 1.47-8.21 |
| Trend test | P = 0.025 | Pa = 0.045 | ||||
| SBP by tertile (mmHg) | ||||||
| ≤ 126 | 87/95 | 1.00 | 87/95 | 1.00 | ||
| 126-130 | 127/96 | 1.12 | 0.55-4.02 | 127/96 | 1.08 | 0.52-3.91 |
| > 130 | 144/96 | 1.68 | 0.43-4.99 | 144/96 | 1.42 | 0.42-4.56 |
| Trend test | P = 0.321 | Pa = 0.614 | ||||
| DBP by tertile (mmHg) | ||||||
| ≤ 82 | 89/95 | 1.00 | 89/95 | 1.00 | ||
| 82-86 | 131/96 | 1.15 | 0.62-6.27 | 131/96 | 1.11 | 0.47-5.98 |
| > 86 | 138/95 | 1.23 | 0.85-5.34 | 138/95 | 1.25 | 0.67-4.21 |
| Trend test | P = 0.457 | Pa = 0.702 | ||||
| FPG by tertile (mmol/L) | ||||||
| ≤ 5.4 | 93/95 | 1.00 | 93/95 | 1.00 | ||
| 5.4-5.7 | 122/95 | 1.22 | 0.52-7.04 | 122/95 | 1.18 | 0.48-6.87 |
| > 5.7 | 143/96 | 1.39 | 0.65-9.22 | 143/96 | 1.29 | 0.57-8.21 |
| Trend test | P = 0.301 | Pb = 0.598 | ||||
| TCH by tertile (mmol/L) | ||||||
| ≤ 5.2 | 89/96 | 1.00 | 89/96 | 1.00 | ||
| 5.2-5.6 | 118/95 | 1.26 | 0.38-7.04 | 118/95 | 1.17 | 0.42-6.11 |
| > 5.6 | 151/95 | 1.61 | 0.58-8.11 | 151/95 | 1.54 | 0.63-6.92 |
| Trend test | P = 0.428 | Pa = 0.779 | ||||
| TG by tertile (mmol/L) | ||||||
| ≤ 1.5 | 67/96 | 1.00 | 67/96 | 1.00 | ||
| 1.5-1.7 | 120/95 | 1.78 | 0.84-7.86 | 120/95 | 1.59 | 0.77-6.82 |
| > 1.7 | 171/95 | 2.54 | 0.97-8.25 | 171/95 | 1.96 | 0.92-7.63 |
| Trend test | P = 0.148 | Pa = 0.253 | ||||
| Ln (FINS) by tertile (mIU/L) | ||||||
| ≤ 1.9 | 71/94 | 1.00 | 71/94 | 1.00 | ||
| 1.9-2.3 | 120/96 | 1.62 | 0.92-5.62 | 120/96 | 1.33 | 0.88-5.14 |
| > 2.3 | 167/96 | 1.97 | 1.08-7.75 | 167/96 | 1.68 | 0.94-6.91 |
| Trend test | P = 0.045 | Pb = 0.161 | ||||
| Ln (HOMA-IR) by tertile | ||||||
| ≤ 1.1 | 62/94 | 1.00 | 62/94 | 1.00 | ||
| 1.1-1.4 | 125/96 | 2.24 | 1.47-7.62 | 125/96 | 1.98 | 1.28-6.08 |
| > 1.4 | 171/96 | 3.47 | 1.83-8.35 | 171/96 | 2.85 | 1.65-7.22 |
| Trend test | P = 0.014 | Pb = 0.026 | ||||
| Ln (omentin-1) by tertile | ||||||
| ≤ 3.14 | 48/96 | 1.00 | 48/96 | 1.00 | ||
| 3.14-3.52 | 91/95 | 1.98 | 1.58-11.83 | 91/95 | 1.83 | 1.44-9.76 |
| > 3.52 | 219/95 | 6.12 | 2.86-10.47 | 219/95 | 5.76 | 1.81-8.95 |
| Trend test | P ≤ 0.001 | Pa = 0.001 | ||||
| Adiponectin (mg/L) | ||||||
| > 14.12 | 59/95 | 1.00 | 59/96 | 1.00 | ||
| 11.35-14.12 | 116/95 | 2.23 | 1.68-9.53 | 116/95 | 2.25 | 1.62-8.04 |
| ≤ 11.35 | 183/96 | 3.61 | 1.92-10.41 | 183/95 | 3.04 | 1.93-8.37 |
| Trend test | P = 0.002 | Pa = 0.019 | ||||
| Leptin (ng/mL) | ||||||
| ≤ 18.56 | 75/94 | 1.00 | 75/94 | 1.00 | ||
| 18.56-23.29 | 129/96 | 1.72 | 0.98-7.55 | 129/96 | 1.17 | 0.74-6.94 |
| > 23.29 | 154/96 | 2.11 | 1.04-10.23 | 154/96 | 1.98 | 0.96-8.73 |
| Trend test | P = 0.042 | Pa = 0.125 | ||||
| Ln (visfatin) by tertile (mg/L) | ||||||
| ≤ 1.42 | 49/96 | 1.00 | 49/96 | 1.00 | ||
| 1.42-1.57 | 131/95 | 3.28 | 1.92-9.02 | 131/95 | 2.74 | 1.78-7.83 |
| > 1.57 | 178/95 | 4.92 | 2.26-11.68 | 178/95 | 3.97 | 1.93-9.97 |
| Trend test | P = 0.001 | Pa = 0.008 | ||||
| Ln (resistin) by tertile (mg/L) | ||||||
| ≤ 1.65 | 54/95 | 1.00 | 54/95 | 1.00 | ||
| 1.65-1.94 | 127/95 | 2.68 | 1.73-10.47 | 127/95 | 1.99 | 1.48-9.36 |
| > 1.94 | 177/96 | 3.74 | 1.98-9.76 | 177/96 | 3.02 | 1.62-7.81 |
| Trend test | P = 0.007 | Pa = 0.016 | ||||
a
Adjusted for age, body mass index (BMI), waist:hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TCH), triglyceride (TG), homeostatic model assessment of insulin resistance (HOMA-IR), omentin-1, adiponectin, leptin, visfatin, resistin, lifestyle characteristics, medications, family history of CRC and diabetes.
b
Adjusted for age, BMI, WHR, SBP, DBP, TCH, TG, omentin-1, adiponectin, leptin, visfatin, resistin, lifestyle characteristics, medications, family history of CRC and diabetes.