Figure 3.

HEIH regulated HG-induced APRE-19 cell injury through negative regulation of miR-939. A: miR-939 expression after transfection with pcDNA-HEIH, si-HEIH, and respective controls. B: miR-939 expression after transfection with miR-939 mimic, miR-939 inhibitor, and their controls. C: Cell viability in the treated groups. D: Cell apoptosis in the treated groups and the expression levels of apoptosis-related proteins. E: Cytochrome C release from mitochondria to cytoplasm in the treated groups. F: Caspase-3 activity in the treated groups. All experiments were repeated three times and the data are presented as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 compared with corresponding controls.