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. 2019 Aug 1;12(8):2898–2908.

Figure 1.

Figure 1

Partial sciatic nerve ligation leads to hind paw mechanical hypersensitivity and elevated astrocytic FGFR3 expression in rat spinal dorsal horn. (A) Ipsilateral hind paw withdrawal thresholds (g) over time measured with von Frey filaments. Rats were tested 0 and 3, 7, 14, and 21 days after either sham or PSNL surgery (SNI). Data represent the mean ± SEM. *P<0.01 vs. sham mice at the corresponding time point. n = 6/group. (B) Immune Fluorescent Staining of GFAP in ipsilateral dorsal spinal cord at 14 days after surgery. Quantification analysis of GFAP positive cells as shown in the right. (C) The expression of FGFR3 in the ipsilateral spinal dorsal horn of SNI and sham rat quantified by western blotting over time (days). The upper quantitative graphs are from representative immunoblot photographs as shown below. Data represent the mean ± SEM. *P<0.01. N = 6/group. (D, E) immunofluorescence for FGFR3 (green) in the ipsilateral spinal dorsal horn of SNI and sham rat (E). Quantification analysis of GFAP positive cells as shown in (D).