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The key to distinguishing between primary thyroid papillary carcinoma and pulmonary metastasis in morphology is that the papillary thyroid carcinoma has a glassy nucleus with a nuclear overlap, sulcus, and inclusion bodies, but in lung cancer it’s invisible, in immunohistochemistry, NapsinA+, TG- can be detected in thyroid metastasis of lung cancer, TG+, Napsin A- for primary thyroid papillary carcinoma.
