Table 1.
Summary of prior reported cases of thyroid metastasis from non-small cell lung cancer
| Series (reference) | Patients’ age and sex | histological type | The location of thyroid metastasis | Clinical presentation | Treatment | Survival |
|---|---|---|---|---|---|---|
| Yaner Yu et al. (our study) | 54/male | adenocarcinoma | right thyroid lobe | a history of slight cough and expectoration | Drug, surgery | No recurrence in one year |
| Boukir A et al. [3] | 51/female | NA | The lower left corner of the thyroid gland, 18*21*27 mm | a persistent, limited and mild pain swelling in the left lobe of the thyroid gland. | NA | NA |
| Megumi Miyakawa. et al. [4] | 50/female | adenocarcinoma | NA | right shoulder pain | combination chemotherapy (paclitaxel:Taxol, 250 mg and CBDCA: Parapratin 525 mg, Bristol Pharmaceutical KK., Tokyo, Japan), gamma-knife radiosurgery | died of respiratory failure in 6 months |
| Narendra Hulikal et al. [5] | 42/female | NA | a 5 cm × 4 cm thyroid swelling and multiple lymph nodes on the right side of the neck levels 2 and 3, largest measuring 3 cm × 2 cm | a 1-month history of swelling in front of the neck and throat pain. | Total thyroidectomy with bilateral selective (levels 2-5) lymph node dissection and central compartment dissection+ chemotherapy. | Under therapy when reported |
| Narendra Hulikal et al. [5] | 42/female | NA | a 5 cm × 4 cm thyroid swelling and multiple lymph nodes on the right side of the neck levels 2 and 3, largest measuring 3 cm × 2 cm | a 1-month history of swelling in front of the neck and throat pain. | Total thyroidectomy with bilateral selective (levels 2-5) lymph node dissection and central compartment dissection+ chemotherapy. | Under therapy when reported |
| Tariq Namad et al. [6] | 48/female | adenocarcinoma | the largest was in the left thyroid | Diagnosed with lung cancer, progressive fatigue, dyspnea, and dysphagia | drug therapy | No recurrence in three months |
| Elliott RH et al. [7] | 64/male | NA | Hard mass in right lobe of thyroid with bilateral, small, firm supraclavicular lymph nodes. | Adyspnea and wheezing in chest for four months | Biopsy of lymph node, frozen section, right thyroid lobectomy. | NA |
| Elliott RH et al. [7] | 60/male | NA | Stony hard, 3 cm. nodule in right lobe of thyroid, not noticed by patient. | 3 month history of crippling low-back pain with radiation down legs. | Total thyroidectomy with pretracheal node and right axillary lymph node dissection and Decompression , operation of sudden atelectasis laminectomy L 2-3 and L 4-5 and palliative x-ray therapy | Die in 7 months after the operation of sudden atelectasis |
| Elliott RH et al. [7] | 67/female | adenocarcinoma | Advanced malignant disease with hard nodular thyroid and fixed left supraclavicular nodes | with gradually enlarging goiter for one year and one month of progressive dyspnea, substernal pain and cough. | Biopsy lymph node. Frozen section “carcinoma”. Total thyroidectomy. | Died 9th postoperative day. |
| Elliott RH et al. [7] | 34/male | squamous cell carcinoma | NA | enlarged lymph nodes in the right neck for one year. | Exploratory with removal of thyroid isthmus. | Died of disease elsewhere 3 months later |
| A. Dao et al. [9] | 59/male | adenocarcinoma | a right thyroid nodule. | dyspnea, dry cough, and chest pain, a smoker | The cranial palliative radiotherapy | Die |
| Wey SL et al. [15] | 64/Male | follicular adenoma | the left thyroid gland was 7.3 × 4 × 3.5 cm in size with one major well-defined nodule, and the right thyroid gland was 5.5 × 4 × 3 cm in size with several nodules. | neck mass, hoarseness, and easy choking | NA | NA |
| Wey SL et al. [15] | 71/female | papillocarcinoma | The right thyroid gland was 4.4 × 2.3 × 1.8 cm in size with one major nodule and several small nodules | NA | a radical thyroidectomy and left lung lobectomy | NA |
NA: not available.